20 Best Anime series like Mass Effect: Paragon Lost (2012)

Shinichi Izumi is a normal high school boy whose right hand has become infected with an alien parasite that names itself "Migi" ("right"). Migi is the first parasite to develop a symbiotic relationship with its host, as he and Shinichi slowly develop a grudging friendship. Migi isn't the only Parasite on earth, however, and as cases of Parasites killing humans begin to emerge, humans seek to kill off Parasites. Shinichi and Migi find themselves caught in between these two sides of the struggle over planet earth.

The story revolves around Duke Fleed who is a survivor of the Vega Star, raised by Dr. Umon as his adoptive son, and known as Daisuke Umon on Earth. Years after his arrival, he's faced with the threat of King Vega and his army, who want to conquer the Earth. With his friends Koji and Hikaru (and later his kid sister Maria Grace), Duke decides to fight back using his best weapon, the almighty Grendizer.

In Japan in the year 2035, an accident known as the "Burst" occurs during a research project, spawning an out-of-control artificial life form called "Matter" that has spread throughout the Kurobe Gorge. The research city that was once hailed as the hope for humanity is cordoned off by the government. Two years later, 15-year-old Aiko Tachibana, who lost her family in the Burst, learns something unbelievable from Yuya Kanzaki, a new student at her school. A secret is hidden within her body, and the answer to the puzzle lies at the "Primary Point" that was the center of the Burst. Aiko resolves to infiltrate the restricted area, escorted by a team of divers and with Yuya as her guide. When boy meets girl with the fate of humanity in their hands, what new truth will come to light?

In 1972, the Apollo 17 mission discovered a hypergate to Mars on the surface of the moon. Soon a war breaks out between Earth and Mars, and Martian soldiers begin to descend from the sky, riding steel giants, intent on exterminating humanity.

Inuyashiki Ichirou is down on his luck. While only 58 years old, his geriatric looks often have him written off as a pathetic old man by the world around him and he’s constantly ignored and disrespected by his family despite all that he’s done to support them. On top of everything else, his doctor has revealed that he has cancer and it appears that he has little time left in this world. But just when it seems things couldn’t get any worse, a blinding light in the night sky strikes the earth where Ichirou stands. He later wakes up to find himself unscathed, but he soon starts to notice that there’s something… different about himself. However, it turns out that these strange, new changes are just what Ichirou needs to take a new lease on life and now it seems like there’s nothing to stop him from being a hero worthy of the respect that he never had before… unless, that is, there was someone else out there with these same changes…

In the early 2050s, unknown life forms called “Oracle cells” begin their uncontrolled consumption of all life on Earth. Their ravenous appetite and remarkable adaptability earn them first dread, then awe, and finally the name “aragami”. In the face of an enemy completely immune to conventional weapons, urban civilization collapses, and each day humanity is driven further and further toward extinction. One single ray of hope remains for humanity. Following the development of “God Arcs”—living weapons which incorporate Oracle cells—their wielders are organized into an elite force.

Forty years ago, the minds of Paradigm City's inhabitants were wiped clean of all recollections of the past. Now, ruled by a powerful corporation and cut off from the rest of the world by desolate wastelands, Paradigm has become a virtual police state where Negotiators like Roger Smith keep the wheels of progress, commerce, and society turning.

In the year 2063, eight high school students and a kid are flown out to Planet Camp, tasked with surviving on their own for a few days. But shortly after arriving, an ominous glowing orb warps them to an unknown quadrant of space, nearly 5,012 light years away. Now, the only way back home is a slow, dangerous trek across the universe—a journey that’ll test them in ways Planet Camp never could.

The story centers around two fiercely fighting schoolgirls, Ryuuko Matoi and Satsuki Kiryuuin. On a campus ruled by force, a transfer student wielding a Basami sword brings about upheaval.

The protagonist, Baki Hanma, trains with an intense focus to become strong enough to surpass his father, Yujiro Hanma, the strongest fighter in the world. Five of the world's most violent and brutal death row inmates are gathering to face Baki. Their objective is to taste defeat -- their unmatched strength and skill have led them to grow bored of life itself, and they now seek out Baki in the hopes that he can overwhelm and utterly crush them. In this crisis, other underground martial art warriors gather to fight by Baki's side: Kaoru Hanayama, Gouki Shibukawa, Retsu Kaioh, and Doppo Orochi. An epic showdown between violent death row inmates and Baki and his friends begins.

One fateful day, all of humanity was petrified by a blinding flash of light. After several millennia, high schooler Taiju awakens and finds himself lost in a world of statues. However, he's not alone! His science-loving friend Senku's been up and running for a few months and he's got a grand plan in mind, to kickstart civilization with the power of science!

Invertia was a meteor storm that caused an unprecedented disaster during the 20th century. Because of this disaster, numerous cities around the world were destroyed. However, within the meteor, an unknown element called mana was discovered. It allowed human technology to make rapid strides giving rise to a new species of super-powered humans, the Star Pulse Generation (Genestella). The Festas (Star Warrior Festivals) host battles between Genestella at a city of six academies called “Rikka,” also commonly known as “Asterisk.”Scholarship student Ayato Amagiri transferred into Seidoukan Academy in order to fulfill his own wish, swearing he too will fight in this city.

Many years have passed since humanity was driven to the brink of extinction by the sudden emergence of the unknown life forms Gadoll. Those humans that survived now dwell in a 3000m-high mobile fortress Deca-dence built to protect themselves from the Gadoll threat.Denizens of Deca-dence fall into two categories: Gears, warriors who fight the Gadoll daily, and Tankers, those without the skills to fight. One day, Natsume, a Tanker girl who dreams of becoming a Gear meets surly Kaburagi, an armor repairman of Deca-dence.This chance meeting between the seemingly two opposites, the girl with a positive attitude who never gives up on her dreams and the realist who has given up on his, will eventually shake the future course of this world.

Several hundred years ago, humans were nearly exterminated by Titans. Titans are typically several stories tall, seem to have no intelligence, devour human beings and, worst of all, seem to do it for the pleasure rather than as a food source. A small percentage of humanity survived by walling themselves in a city protected by extremely high walls, even taller than the biggest Titans. Flash forward to the present and the city has not seen a Titan in over 100 years. Teenage boy Eren and his foster sister Mikasa witness something horrific as the city walls are destroyed by a Colossal Titan that appears out of thin air. As the smaller Titans flood the city, the two kids watch in horror as their mother is eaten alive. Eren vows that he will murder every single Titan and take revenge for all of mankind.

The story is set in the distant future. The land is ruined, and humanity establishes the mobile fort city Plantation. Pilots produced inside Plantation live in Mistilteinn, also know as the "birdcage." Children live there knowing nothing of the outside world or the freedom of the sky. Their lives consist of battling to carry out missions. Their enemies are mysterious giant lifeforms known as Kyouryuu, and the children pilot robots called Franxx to face off against them. For the children, riding the Franxx proves their existence. A boy named Hiro is called Code:016, and he was once known as a prodigy. However, he has fallen behind, and his existence seems unnecessary. Not piloting a Franxx is the same as ceasing to exist. One day, a mysterious girl known as "Zero Two" appears before him. Two horns grow out of her head.

A near future, where humans have been defeated by the viral parasites named Gastrea. They have been exiled into a small territory and live in despair, side-by-side in terror.In this world trapped in darkness—Rentaro, a boy living near Tokyo and member of the "Civil Security"—an organization specializing in fighting against the Gastrea—is used to accomplishing dangerous tasks. His partner is Enju, a precocious young girl. They fight thanks to their peculiar powers until one day, when they receive a special assignment from the government. This top secret mission is to prevent the destruction of Tokyo...Set in a near future, this thrilling heroic-action story... starts now!

Legendary half-vampire, half-human vampire hunter Blade is tracking Deacon Frost, a very powerful and influential vampire who killed his mother and who heads Existence, a secretive vampire organization that operates in Southeast Asia.

Based on Sakyo Komatsu's 1973 bestseller sci-fi novel "Japan Sinks." The story is set right after the 2020 Tokyo Summer Olympics, and follows the fate of the four members of the Muto family, including the protagonist girl Ayumu and her younger brother Gou.

Karen Kohiruimaki always felt out of place in the real world. Due to her extreme height, she found it hard to make friends with other girls her age. Everything changes when she's introduced to VR and Gun Gale Online. In GGO, Karen is free to play the cute, chibi avatar of her dreams! Can Karen find friendship in this bullet-ridden MMO...?

15 years ago, an unknown hyperspace gate opened over the Pacific. Beyond this gate lies Reto Semaani, a strange alternate world where fairies and monsters live.San Teresa City—a city where over two million immigrants live from both worlds. As a result, there are the haves and the have-nots. Here is the world's newest "city of dreams." But in the shadow of the chaos, crime is rampant: drugs, prostitution, and weapon trafficking. The detectives who stand up to these heinous crimes are in the San Teresa City Police. When the detective Kei Matoba and the alternate-world knight Tirana—two individuals who differ in gender, personality, and even world of origin—meet, an incident erupts. Two worlds. Two justices. From this, the curtain rises on a buddy police action story!

When an island half-disappears from the face of the earth, a mysterious organization sends out invitations for a tournament to every skilled fighter in the world. "If you win you can have ANYTHING you want," they claim. They're recruiting only the best to fight the best and claim the title of The God of High School. Jin Mori, a Taekwondo specialist and a high school student, soon learns that there is something much greater beneath the stage of the tournament.

On a continent ruled by chaos, the Lords have the power of a holy seal that can calm the chaos and protect the people. However, before anyone realizes it, the rulers cast aside their creed of purifying the chaos, and instead start to fight each other for each other's holy seals to gain dominion over one another. Siluca, an isolated mage who scorns the Lords for abandoning their creed, and a wandering knight named Theo, who is on a journey to train to one day liberate his hometown, make an everlasting oath to work together to reform this continent dominated by wars and chaos.

Angel Beats takes place in the afterlife and focuses on Otonashi, a boy who lost his memories of his life after dying. He is enrolled into the afterlife school and meets a girl named Yuri who invites him to join the Afterlife Battlefront — an organization she leads which fights against God. The Battlefront fight against the student council president Angel, a girl with supernatural powers.

The anime's story is set in the year 2202, three years after the Yamato's return from the planet Iscandar. The people of Earth restored their planet with the Cosmo Reverse System, and they signed a peace treaty with Garmillas. In addition to reconstruction, Earth developed a new defense fleet that includes the state-of-the-art battleship Andromeda. The Earth goes down a path of military expansion, despite Starsha Iscandar's wishes. The Yamato helps accomplish this so-called peace, but it comes at the price of many invaluable sacrifices. The goddess Teresa, who prays for tranquility in space, calls the Yamato to a new voyage. The threat of Gatlantis is sweeping over the universe and approaching Earth.

High-school girl Yuri suddenly finds herself on the rooftop of a high-rise building. She's trapped in a bizarre world surrounded by skyscrapers, where a masked man cracked open a man's head with an axe before her eyes. Finding a way to survive this bizarre world, find her beloved brother, and escape becomes her top priority, but she is beset by danger not just from the mysterious Masks, which possess both inhuman strength and cruelty, but other survivors turned cruel or desparate by the insanity of the high-rise world.

During the construction of the Kurobe Dam, an ancient artifact was discovered, and so the United Nations Kurobe Research Institute was established. Intellectuals from all over the world gathered to study the object, and the children of those researchers attend Mt. Tate International Senior High School, including the institute head's daughter, Yukina Shirahane. In the summer of 2016, a lone samurai once again awakens.

Wolverine is a mutant, possessing animal-keen senses, enhanced physical capabilities, three retracting bone claws on each hand and a healing factor that allows him to recover from virtually any wound, disease or toxin at a accelerated rate.

The story follows Eren Yeager and Mikasa Ackerman entering Titan Jr. High, a school where humans and Titans study in the same area in coexistence. Because of a "traumatic" event, where the Colossal Titan ate his lunch back in middle school, Eren hates the Titans, and is constantly trying to find a way to rid the earth of their kind. Because of this, he has a hard time making friends, much to Mikasa's worry.

Many years ago, a Great Civil War ravaged Japan, leaving the country fragmented between two regions: Kansai and Kanto. In Kansai, a group of six Akudama carry out missions given to them by a mysterious black cat, while evading the police. But a dangerous journey is about to unfold when a civilian girl becomes twisted into the Akudama's way of life and witnesses their criminal drives.

The one adored as the mother is not the real parent. The people living here together are not actual siblings. The Gracefield House is where orphaned children live. An irreplaceable home where 38 siblings and Mom live happy lives, even with no blood relations. However, their everyday life suddenly came to an abrupt end one day...

With a maintenance robot and a deadly fugitive tagging along, friendship droid S.A.M searches for its best friend, the heir to a kingdom under siege.

Girls from all over the world gather at IS Academy to learn how to become IS pilots. However, since Ichika can somehow pilot the IS even though he is male, he was forced to attend IS Academy as the only male in this school.

The story revolves around Kaiman, who does not remember who he was before he was transfigured by a Magic user. This transformation left him with a reptile's head, and a desire to find out the truth about who he really is. Accompanied by Nikaido, his female companion, he tracks down Magic Users in "The Hole" and unceremoniously chomps down on their head, hoping to find out who it was that put him in this state. One by one, they witness this "second man" inside the head of Kaiman, and after pulling them back out of his mouth he asks them all a question... "What did the guy inside my head say?"

In the 2030s Earth has been overrun by the Blue, which are mutated insect-like creatures that kill and harvest humans for food. Most of the surviving human race has moved to Second Earth, a huge spaceship that orbits the planet. Yuji and Marlene must work together to reach Second Earth and fight against the Blue.

Brought together by a mysterious song, a grad student and an engineer lead the fight against an unimaginable force that may spell doom for the world.

For Brandon Heat, death doesn't matter. Driven by his need for revenge, he returns from beyond the grave to cripple Milleneon, the huge mafia organization which uses undead monsters as its enforcers. His ultimate goal is to destroy Harry MacDowel, the leader of Milleneon and, at one time, Brandon's best friend...

In the year 2045, after global capitalism has defaulted, Japan's elite Section 9 begins conducting covert cyber operations.

Tokyo is abuzz with persocoms – humanoid computers that are virtually perfect. The socially and technologically inept Hideki is dying to get his hands on one. When he finds Chii abandoned in the trash, she’s cuter than any current model he’s ever seen before. But when he gets her home and turns her on, she has no data and only a single learning program installed. While Hideki puts his whole heart into teaching Chii the ins and outs of humanity, a mystery unfolds as a dark secret within her awakens.

Following the success in the Camelot Singularity, Ritsuka Fujimaru and Mash Kyrielight are assigned to the last Singularity in the Grand Order initiative. In Ancient Babylonia, 2500 BCE, they embark on a mission to secure humanity's survival. Upon arrival, they learn that three gods have threatened Uruk, the Babylonian city ruled by King Gilgamesh. Ritsuka and Mash must work together to fend off the invasion of mysterious beasts in Uruk under Gilgamesh's orders while investigating the true nature of the three gods' actions against humanity; but unknown to Ritsuka, an ancient entity is slowly rising from its slumber.

Eager to follow in the footsteps of his fallen sister, Kazuya enrolls at West Genetics Academy, a training facility for buxom heroes known as Pandoras. These courageous schoolgirls are genetically-enhanced with enough sex appeal to cripple a man – and the superhuman strength to slaughter aliens by the dozen. Kazuya’s role is that of Limiter, a Pandora’s battle partner, and he quickly sets his sights on the most feared beauty in school, Satellizer el Bridget. This full-figured annihilator of aliens is as desirable as she is deadly, but rubbing her the wrong way could lead to gross bodily harm. Can Kazuya forge a bond with his new partner and rise to the top of the ranks at West Genetics? Or will he fall victim to the mysterious bloodlust lurking within Satellizer?