20 Best Anime series like Life Lessons with Uramichi Oniisan (2021)

Alcohol, smoking, and stress—in the body subjected to these irritants, the cells responsible for maintaining life seem to fight a war that never ends. Due to a severe shortage of workers, Red Blood Cell AA2153 has to quickly learn to deliver oxygen and collect carbon dioxide, even in dangerous conditions. Meanwhile, White Blood Cell U-1196 has to do her part by dealing with germs and viruses during life-threatening situations. In the midst of these crises, they have to work together to keep the body healthy, despite not knowing if their sacrifices will be worthwhile. Cells at Work! Code Black takes a different approach by showing the grittier side of the jobs our cells perform.

A high school student named Yachi Haruaki receives a mysterious, super-heavy black cube from his father overseas. That night, Haruaki wakes up to a suspicious noise in the kitchen, and he discovers a fully naked female thief of rice crackers. The girl, Fear, is the first of several surprises that Haruaki receives.

By force of circumstances, a 30-year-old single man with a full-time job suddenly starts raising a 6-year-old girl. While running each other ragged, the two of them gradually grow into a "family".

Aoi prefers indoor hobbies and is afraid of heights, but her childhood friend Hinata loves to show off her passion for mountain climbing. As young children they once watched the sunrise from the top of a mountain, and now they've decided to take up mountain climbing in hopes of seeing that sunrise again. They have cooking battles with mountaineering gear, climb small hills in their neighborhood, and meet new mountaineering friends as they learn the ropes of the hobby. When will they finally see that sunrise again?

A blush-inducing, coming-of-age comedy about manga-loving book store employees!! The unique cast of characters -- all hard-core manga fans and maniacs of some sort -- work at comic shop “Uma no Hone.” On a daily basis, they display new releases, shrink-wrap comics, shudder at their lack of feminine qualities, question their love for porn literature…and basically have fun while working hard (?). Girls and guys call each other by nicknames and some begin to develop close relationships! It’s non-stop humor and romance in this book store rom-com!

Kagami Junichirou was known as a physics genius when he was a teenager, and he was even published in "Nature." However, after college, he suddenly lost all interest in science. As a NEET, he's devoted himself to his anime blog and nerdy collecting habits. He claims he has a serious illness called "I can't do anything I don't want to do." Desperate to get him to do something with his life, his little sister manages to get him a job teaching physics at his old high school. He's certainly an unconventional teacher, but he becomes fairly popular with the students. After helping a girl who's being ruthlessly bullied, Kagami finds that he actually likes teaching. Will he continue his career as a weird teacher? Will he go back into physics? Or will he end up back where he started?

Misha is a little girl who lost her mother at an early age, and now lives with her father. Her father employs a maid named Tsubame, who was a former Self-Defense Force official, and is also a lolicon.

The story of Mikazuki Subaru, a novelist who is shy and struggles in relationships with other people, and a cat who was dumped by humans and lived a tough life on the streets. Through a twist of fate, the two of them end up living together. This heartwarming tale illustrates day-to-day life through the eyes of both man and cat. These moments seem trivial, but as they build upon themselves, the two become family and find happiness in their life together.

Fuutarou Uesugi is a poor, antisocial ace student who one day meets the rich transfer student Itsuki Nakano. They argue but when Uesugi realizes he is to be her tutor, he tries to get on better terms. While trying to do so he meets four other girls.

Mizutani Shizuku finds peace in her studies.  Working hard to stay at the top of the class, alone but focused.  When she is tasked with delivering class materials to Yoshida Haru, her world starts to rapidly expand.  With some new friends and feelings, will she be able to stay focused on her studies?

Foiled by a hero when he’s inches away from conquering the world, the devil finds himself in modern-day Tokyo. With no real-world skills to speak of, the devil is forced to make ends meet flipping burgers at a fast food joint! To stall any further plans of world domination, the hero tracks the devil’s trail and takes on the lowly tasks of a telemarketer.

"Miss Bernard" herself, Machida Sawako, and her book-loving friends live their literary days in the library. This gag series glorifying famous literature is filled with love for books of all sorts, as well as the kinds of things that all readers experience!

Humans have created a Wall of Severance to separate themselves from the bears, who grew violent and attacked humans after a far-off planet known as Kumalia exploded many years ago, turning into a meteor shower that fell upon earth. Two bears, Ginko Yurishiro and Lulu Yurigasaki, sneak through the Wall of Severance and disguise themselves as humans, enrolling in Arashigaoka Academy and taking an interest in Kureha Tsubaki, a human girl who despises bears.

While spending summer with his mother, Haru meets Ren, a boy newly adopted by his mother. Getting along with Ren isn't easy as Haru's goal is to "civilize" him by the time summer ends. Their relationship slowly improves as Haru spends more time with Ren and in return Ren steadily warms up to him. Can they really become a "family" at the end of summer?!

A Kiss Note is a powerful notebook that makes anyone who has their name written together will instantly fall in love if they kiss each other regardless of any circumstances. This magical and very familiar item belongs to an angel named Guri whose job as cupid is to create couples. However, she accidentally writes down Aino Seiji, a regular high school student, and unless he kisses someone, Guri will die. She convinces Seiji to go kiss his crush, Hiyama Akane, the school's popular girl who turns out has even stronger feelings for him, bordering on obsessive and psychotic. Eventually Akane and Seiji come together but not before Guri decides that she likes Seiji as well. What seems awesome to most guys becomes hell for Seiji who just wants a normal relationship with girls.

Every day an epic struggle rages in grocery stores across Japan—the battle for half-priced bento boxes! Once the discount stickers go on, ravenous brawlers start throwing punches in a knockdown, drag-out war over who gets to take home the cheap eats. When a young, broke high school student named Sato joins the Half-Priced Food Lovers Club, he proves to be a rising talent in the world of insane food fights. But does he have what it takes to become the king of clearance cuisine? From the director of Black Cat comes a very different type of hunger games. Welcome to the world of Ben-To, where chopsticks are lethal weapons, the supermarket is a battleground, and there’s nothing more delicious than a deep-fried win

Three years ago, the world learned that harpies, centaurs, catgirls, and all manners of fabulous creatures are not merely fiction; they are flesh and blood - not to mention scale, feather, horn, and fang. Thanks to the "Cultural Exchange Between Species Act," these once-mythical creatures have assimilated into society, or at least, they're trying. When a hapless human teenager named Kurusu Kimihito is inducted as a "volunteer" into the government exchange program, his world is turned upside down. A snake-like lamia named Miia comes to live with him, and it is Kurusu's job to take care of her and make sure she integrates into his everyday life.

Just when Masato thought that a random survey conducted in school was over, he got involved in a secret Government scheme. As he was carried along with the flow, he ended up in a Game world! As if that wasn't enough, shockingly, his mother was there as well! It was a little different from a typical transported to another world setting, but after some bickering,"Mom wants go on an adventure together with Maa-kun. Can mom become Maa-kun's companion?"With that, Masato and Mamako began their adventure as a mother and son pair. They met Porta, a cute traveling merchant, and Wise, a regrettable philosopher. Along with their new party members, Masato and co. start on their journey.

The story centers around two fiercely fighting schoolgirls, Ryuuko Matoi and Satsuki Kiryuuin. On a campus ruled by force, a transfer student wielding a Basami sword brings about upheaval.

Mitsuka Souji is a first year high school student who greatly loves twintails. One day, a beautiful girl named Thuearle, who comes from another world, suddenly appeared in front of him and gave him the power to transform into the twintails warrior Tail Red. Now Souji must fight in order to protect the peace on Earth with the help of his childhood friend Tsube Aika, who can become the twintails warrior Tail Blue, all while keeping the twintails warriors' real identities hidden and dealing with the fact that Tail Red is actually female

An art club in a certain middle school, and its members: Subaru Uchimaki, who is a genius at drawing faces, but only wants to draw the perfect 2D wife; Colette, a rich troublemaker who never stops making mischief; and the club president, who sleeps through sessions and collects sleeping aids. Mizuki Usami is the only person in the club who wants to do art club-like activities, and constantly struggles to do so.

"If you blush, you lose."Living by this principle, the middle schooler Nishikata gets constantly made fun of by his seat neighbor Takagi-san. With his pride shattered to pieces, he vows to turn the tables and get back at her someday. And so, he attempts to tease her day after day, only to find himself victim to Takagi-san's ridicule again sooner than later. Will he be able to make Takagi-san blush from embarrassment even once in the end?

The anime centers on four girls at the full bloom of their youth, working hard to achieve their dreams as they struggle valiantly. In Japanese entertainment, Maesetsu! refers to an introductory talk or explanation addressed to the audience before the broadcast of television programs, usually performed by assistant directors and particularly comedians in variety or comedy shows.