19 Best Anime series like Angelic Layer (2001)

After failing his college entrance exams, 18 year-old Tsukasa Mizugaki is offered a position at the renowned SAI Corporation, known for its production and management of Giftia, androids that possess human emotions. Tsukasa’s position is in the terminal service department where the main job is to recover Giftias that are close to their expiration, a graveyard department in every sense. To make matters worse, Tsukasa is ordered to work with Isla, a female Giftia who is never given any responsibility other than serving tea to co-workers.

Invertia was a meteor storm that caused an unprecedented disaster during the 20th century. Because of this disaster, numerous cities around the world were destroyed. However, within the meteor, an unknown element called mana was discovered. It allowed human technology to make rapid strides giving rise to a new species of super-powered humans, the Star Pulse Generation (Genestella). The Festas (Star Warrior Festivals) host battles between Genestella at a city of six academies called “Rikka,” also commonly known as “Asterisk.”Scholarship student Ayato Amagiri transferred into Seidoukan Academy in order to fulfill his own wish, swearing he too will fight in this city.

After a family tragedy turns her life upside down, 16-year-old high school student Tohru Honda takes matters into her own hands and moves out… into a tent! Unfortunately for her, she pitches her new home on private land belonging to the mysterious Soma clan, and it isn't long before the owners discover her secret. But, as Tohru quickly finds out when the family offers to take her in, the Somas have a secret of their own—when hugged by the opposite sex, they turn into the animals of the Chinese Zodiac!

Segawa Yuta is a freshman of a university. He lost his parents when he was small and was raised by his sister Yuri. Yuta has been living alone since Yuri got married to a middle aged man when Yuta was a junior high student.  One day, Yuri visited Yuta's apartment and asked him to take care of her three daughters while Yuri and her husband were on a trip. He unwillingly accepted the job but the plane Yuri took went missing. In order to prevent the daughters from being adopted separately by relatives, Yuta decided to take in all three girls.  A life of a strange family in a tiny apartment begins.

At the end of her first year of high school, Futaba Yoshioka suddenly has a chance encounter with her first love, Kou Tanaka. Three years ago, he transferred schools before she was able to say how she felt about him. After meeting each other again, Futaba realizes that he has gone through many changes. He acts more cool and even had his last name changed to Mabuchi. Gradually the two rekindle their love while piecing together what had happened in the time that they were apart.

Moriko Morioka is a 30-year-old single NEET woman. After dropping out from reality, she has taken off in search for a fulfilling life and ended up in a net game or "netoge." In the netoge world, she began her new life as a refreshing and handsome character named Hayashi. While starting out as a beginner, a pretty character named Lily reached out to help her. Meanwhile, in the real world, awaits a shocking encounter with a good-looking elite company employee, a mysterious blue-eyed blonde.

When bespectacled Yuki Akamatsu joins his school’s 2nd Newspaper Club, he finds himself caught in the crossfire between three pretty panelists assigned to the Life Advice column. Rino Endo has a mind for science, Fumi Kujo loves literature, and Izumi Suzuki covers the world of sports. If students have questions that need answers, these are the girls to ask, but cute as they may be, these panelists never seem to agree on anything! Needless to say, navigating life in the 2nd Newspaper Club is gonna be more than poor Yuki bargained for!

The Diclonius, a mutated homo sapien that is said to be selected by God and will eventually become the destruction of mankind, possesses two horns in their heads, and has a "sixth sense" which gives it telekinetic abilities. Due to this dangerous power, they have been captured and isolated in laboratories by the government. Lucy, a young and psychotic Diclonius, manages to break free of her confines and brutally murder most of the guards in the laboratory, only to get shot in the head as she makes her escape. She survives and manages to drift along to a beach, where two teenagers named Kouta and Yuka discovers her. Having lost her memories, she was named after the only thing that she can now say, "Nyuu," and the two allow her to stay at Kouta's home. However, it appears that the evil "Lucy" is not dead just yet...

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In the 2030s Earth has been overrun by the Blue, which are mutated insect-like creatures that kill and harvest humans for food. Most of the surviving human race has moved to Second Earth, a huge spaceship that orbits the planet. Yuji and Marlene must work together to reach Second Earth and fight against the Blue.

Pacifica Casull is the most feared and hated person by the followers of the God Mauser. Known as the Scrapped Princess, she is the poison that will destroy the world. To avoid being killed by the zealots of Mauser, Pacifica and her adoptive brother and sister leave the village of Manhurin. Her brother, Shannon, is an expert with the sword while Racquel is proficient with magic. At every step of the way, however, someone is constantly trying to kill Pacifica, hoping to somehow avert the catastrophe that is supposed to befall the world on her 16th birthday.

Aishiteruze Baby is a shōjo romance manga by Yoko Maki. It was serialized by Shueisha in Ribon from April 2002 and January 2005 and collected in seven bound volumes. It was adapted as a 26-episode anime television series produced by TMS Entertainment and Animax, broadcast in Japan on Animax from April to October 2004. The series is about a teenage boy, Kippei, who becomes the caretaker of his 5-year-old cousin, Yuzuyu, after her mother abandons her. Both the manga and anime have been praised for successfully mixing serious issues with a light-hearted tone.

Yukito Kunisaki is on a journey in search of the Winged Maiden who was bound to the sky centuries ago, after hearing an old childhood tale from his mother. As Yukito shows his puppet show to people in an attempt to make some money, he finds himself in a small town in which he did not expect to stay very long. However, when he meets an unusual girl named Misuzu, things take a drastic turn as he is invited to stay with her. By staying in the quaint town, Yukito soon becomes friends with the locals. As he gets to know them better, he learns of their problems and decides to help, putting his search for the Winged Maiden on hold. With his search on hold, and his growing attachment to Misuzu and the small town, will Yukito ever find the Winged Maiden, or is she closer than he thought? [Written by MAL Rewrite]

Tohru Honda is 16 year old orphaned girl who gets invited to live in the house of her classmate, the handsome boy Sohma Yuki, and his cousins, 16 year old Kyo and 27 year old Shigure. However, these young men and parts of the rest of their family (both close and distant) hold a curse; if they are hugged by the opposite gender, they transform into animals of the Chinese Zodiac. Everyday is an adventure for sweet Tohru, as she gets to know everyone in the large family better (especially Yuki and Kyo), in both common and bizarre situations. But, the Sohma Family curse is certainly no laughing matter... it also holds horrible cruelty and heartbreak.

Raised up in the same orphanage, Fuuka and Rinne were once close friends but parted company after a quarrel ended up with Rinne overwhelmed Fuuka with her martial art skills. Fuuka has a life in poverty after leaving the orphanage. An accidental encounter with renowned martial arts champion Einhard Stratos discovered Fuuka's hidden talent in fighting; Einhard offered Fuuka a job and coaching, encouraging her to meet up with Rinne again — in a ring.

A 15-year-old Hitotose Chitose moves out of the orphanage back to his vacant parents' house and finds himself very alone and unhappy. But when five of his female high school teachers decide to move in with him to become his new mamas, he learns that the chaos of their constant attention and concern change his life for the better, if only to teach him about the very special meaning of being part of a family and enjoying a quiet moment.Each of his new mothers has something special to share with him; an artistic cosplay princess, a nurturing supportive homeroom mother, a rowdy athletic sports fanatic, a priestess (sword miko) high school nurse mother, and a quiet secretive (possibly mad) science teacher/mother. These five adoptive mothers accept not only Chi-kun, but also his two sisters...

Nana is a 2006 anime series based upon the manga of the same name. It centers on two girls with the same name and of the same age, crossing paths and ending up living together in Tokyo.

Yuichi hasn’t seen his cousin Nayuki in years. Now that he’s back, all knowledge of ever visiting has vanished. He tries to adjust to the vaguely familiar surroundings, but the gaps in his memory haunt him as time grows short. The pieces of the puzzle have appeared – an eerily silent beauty with blazing tresses, the mysterious girl with the winged backpack, and the sword-wielding demon slayer – but it’s up to Yuichi to discover how they fit together.

High schooler Yūta Iridatsu has experienced “astral projection” i.e. his spirit has been separated from his body. He woke up in a mansion named Koraikan and met a cat spirit named Chiranosuke, who told him “You must find the Sacred Tome of Koraikan in order to return to your physical body.” While searching through corridors of Koraikan, Yūta bumped into underpants of its female residents, and doing so would, eh, create some big trouble for planet Earth.